Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738

M Sawada, K Washizuka, H Okumura

Index: Sawada, Masae; Washizuka, Ken-Ichi; Okumura, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 633 - 637

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Citation Number: 13

Abstract

The synthesis and biological properties of a novel squalene epoxidase inhibitor, FR194738, are described. This compound displayed potent in vitro inhibitory activities against squalene epoxidase and cholesterol synthesis, and lowered plasma cholesterol and triglyceride levels in dogs.