Helvetica chimica acta

Selective Monoderivatization of Propane??1, 3??diamine with Acid Chlorides:'Hexahydropyrimidine method'vs. statistic methods

C Jentgens, S Bienz, M Hesse

Index: Jentgens, Christian; Bienz, Stefan; Hesse, Manfred Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1133 - 1143

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Citation Number: 11

Abstract

Abstract The selective N-monoderivatization of propane-1, 3-diamine (5) with carbonyl and sulfonyl chlorides via2-phenylhexahydropyrimidine (6) was compared with the direct statistic monoderivatization. It was found that, under optimized conditions, both methods are competitive to one another, depending, however, strongly on the reactivity of the eleclrophile used. The 'hexahydropyrimidine method'is more reliable with respect to yields, which are ...