The Use of Various Aminomalonates in the Synthesis of α-Substituted Tryptophans

HM Kissman, B Witkop

Index: Kissman; Witkop Journal of the American Chemical Society, 1953 , vol. 75, p. 1967,1971

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Citation Number: 21

Abstract

Dibenzyl formaminomalonate (IV), carbobenzyloxyaminomalonate (V) and formaminopiperidinomethylmalonate (11) were prepared and tested in condensation reactions with 2-phenyl-and 2-carbethoxy-3-diethylaminoindoles(VI11 and IX). XIII, the condensation product of V with IX, on catalytic debenzylation lost all three benzyl groups and gave 2-carbethoxytryptophan (XIX) in good yield. 2-Phenyltryptophan (XXI) and its ...