Synthesis and antitubercular activity of substituted phenylmethyl-and pyridylmethyl amines

…, N Saxena, VK Tiwari, SS Verma, V Chaturvedi…

Index: Tripathi; Saxena, Nisha; Tiwari; Verma; Chaturvedi, Vinita; Manju; Srivastva; Gaikwad; Sinha Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8186 - 8196

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Citation Number: 24

Abstract

A total of 42 benzyl-and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of Mycobacterium tuberculosis. Many of the ...