A convenient synthesis of chrysin-7-yl aryl N-bis (2-chloroethyl) phosphoramidate
X Chen, J Yuan, J Wang, L Qu, Z Yu…
Index: Chen, Xiaolan; Yuan, Jinwei; Wang, Junliang; Qu, Lingbo; Yu, Zhangqi; Zhao, Yufen Journal of Chemical Research, 2010 , # 7 p. 407 - 409
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Abstract
Chrysin (4), which is widely distributed in plants, has antio- xidant,1 antibacterial,2 anticancer,3 anti-inflammatory,4 antial- lergic,5 and anxiolytic antivities.6 Efforts to improve the biological activity of chrysin have led to the development of derivatives by appropriate modification of chrysin.7,8 The concept of carrier molecules has been employed in the design of some of the earliest nitrogen mustard derivatives used in cancer chemotherapy.9,10 In the past, ...
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