Advanced Synthesis & Catalysis

Green and Scalable Aldehyde??Catalyzed Transition Metal??Free Dehydrative N??Alkylation of Amides and Amines with Alcohols

Q Xu, Q Li, X Zhu, J Chen

Index: Xu, Qing; Li, Qiang; Zhu, Xiaogang; Chen, Jianhui Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 73 - 80

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Citation Number: 36

Abstract

Abstract In contrast to the borrowing hydrogen-type N-alkylation reactions, in which alcohols were activated by transition metal-catalyzed anaerobic dehydrogenation, the addition of external aldehydes was accidentally found to be a simple and effective protocol for alcohol activation. This interesting finding subsequently led to an efficient and green, practical and scalable aldehyde-catalyzed transition metal-free dehydrative N-alkylation method for a ...

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