Tumor inhibitors. 70. Structure-cytotoxicuty relations among N-acyltriamines related to solapalmitine

SM Kupchan, G Bondesson…

Index: Kupchan,S.M. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 65 - 68

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Citation Number: 9

Abstract

The results of a study directed toward determination of the structural requirements for growth- inhibitory activity among N-acyltriamines and other relatives of solapalmitine (1) are reported. Most of the synthetic derivatives were prepared via hydrogenation of tertiary aminonitriles (4) to the appropriate secondary amines (5) and acylation to the N- acyltriamines (6). It was found that, for maximal cytoxicity, N-acyltriamines require an acyl ...