Synthesis and bioevaluation of a series of alkyl ethers of p??N, N??Bis (2??chloroethyl) aminophenol

…, JE Wynn, RL Beamer, CT Bauguess

Index: Wise; Wynn; Beamer; Bauguess Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 5 p. 561 - 565

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Abstract

Abstract A series of even numbered normal alkyl ethers (C 2-C 14) of pN, N-bis (2- chloroethyl) aminophenol were synthesized and evaluated as to acute toxicity in mice and effects on survival in L-1210 leukemic mice. All of the ether derivatives demonstrated significantly lower acute toxicity than the parent phenol mustard. Significant survival times (≧ 125%) were obtained with all compounds except the hexyl derivative. The decyl ether ...