Folate antagonists. 22. Antimalarial and antibacterial effects of 2, 4-diamino-6-quinazolinesulfonamides

…, NL Colbry, J Davoll, MP Hutt, JL Johnson…

Index: Elslager; Colbry; Davoll; Hutt; Johnson; Werbel Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1740 - 1743

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Citation Number: 22

Abstract

The even greater activity uncovered with the development of the 6-arylthio analogues represented by 11, demonstrating the utility of a S spacer coupled with the possibility of introducing a dual inhibitory mechanism; ie, inhibition, of PABA incorporation along with DHFR inhibition encouraged the preparation of a series of 2, 4-di-amino-6- quinazolinesulfonamides 111. The synthesis and biological activity of this series are the ...