A DMAP-catalyzed mild and efficient synthesis of 1, 2-dihydroquinazolines via a one-pot three-component protocol

…, R Boulcina, G Kirsch, B Carboni, A Debache

Index: Derabli, Chamseddine; Boulcina, Raouf; Kirsch, Gilbert; Carboni, Bertrand; Debache, Abdelmadjid Tetrahedron Letters, 2014 , vol. 55, # 1 p. 200 - 204

Full Text: HTML

Citation Number: 11

Abstract

Abstract An efficient and simple method for the synthesis of 1, 2-dihydroquinazolines catalyzed by 4-(N, N-dimethylamino) pyridine (DMAP) from readily available aromatic or heteroaromatic aldehydes, 2-aminobenzophenone, and ammonium acetate under mild conditions is described. The scope and limitations of the method are discussed.

Related Articles:

Recyclable graphite oxide promoted efficient synthesis of 2-phenyl quinazoline derivatives in the presence of TBHP as an oxidant

[Karnakar; Kumar, A. Vijay; Murthy, S. Narayana; Ramesh; Nageswar Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4613 - 4617]

Synthesis of 4-(2-diphenylphosphino-1-naphthyl)-2-phenylquinazoline; a potential P N chelating ligand for asymmetric catalysis

[Gautheron Chapoulaud; Audoux; Ple; Turck; Queguiner Tetrahedron Letters, 1999 , vol. 40, # 51 p. 9005 - 9007]

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

[Huang, Cheng; Fu, Yuan; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Chemical Communications, 2008 , # 47 p. 6333 - 6335]

Ring-Opening Rearrangements of 2-(Benzotriazol-1-yl) Enamines and a Novel Synthesis of 2, 4-Diarylquinazoline

[Katritzky, Alan R.; Yang, Baozhen; Jiang, Jinlong; Steel, Peter J. Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 246 - 249]

An efficient synthesis of quinazolines: a theoretical and experimental study on the photochemistry of oxime derivatives

[Alonso, Rafael; Caballero, Alegria; Campos, Pedro J.; Sampedro, Diego; Rodriguez, Miguel A. Tetrahedron, 2010 , vol. 66, # 25 p. 4469 - 4473]

More Articles...