Tetrahedron Letters

Studying the reactivity of (phthalazin-1 (2H)-on-2-yl) methyl trichloroacetimidate towards different C-and O-nucleophiles

AOH El Nezhawy, ST Gaballah, MAA Radwan

Index: El Nezhawy, Ahmed O.H.; Gaballah, Samir T.; Radwan, Mohamed A.A. Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6646 - 6650

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Citation Number: 6

Abstract

A simple and efficient synthesis of phthalazin-1 (2H)-one 2-substituted derivatives is achieved in very good yields via reaction of a phthalazinone–trichloroacetimidate with various C-and O-nucleophiles such as aromatic, heteroaromatic and olefinic reagents, sugars and cholesterol in CH2Cl2 in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate (TMSOTf).