Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

…, AG Moglioni, M González, LM Finkielsztein

Index: Caputto, Maria E.; Fabian, Lucas E.; Benitez, Diego; Merlino, Alicia; Rios, Natalia; Cerecetto, Hugo; Moltrasio, Graciela Y.; Moglioni, Albertina G.; Gonzalez, Mercedes; Finkielsztein, Liliana M. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6818 - 6826

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Citation Number: 40

Abstract

In the present work, we synthesized a series of thiosemicarbazones derived from 1- indanones with good anti-Trypanosoma cruzi activity. Most of them displayed remarkable trypanosomicidal activity. All the compounds showed nonspecific cytotoxicity on human erythrocytes. The ability of the new compounds to inhibit cruzipain, the major cysteine protease of T. cruzi, was also explored. Thiosemicarbazones 12 and 24 inhibited this ...