Steroids

Synthesis and characterization of the 6α-and 6β-hydroxylated derivatives of corticosterone, 11-dehydrocorticosterone, and 11-deoxycortisol

…, KT van Wee, BG Wolthers, JC van der Molen…

Index: Kraan, Gijsbert P. B.; Wee, Kees T. van; Wolthers, Bert G.; Molen, Jan C. van der; Nagel, Gijs T.; et al. Steroids, 1993 , vol. 58, # 10 p. 495 - 503

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Citation Number: 3

Abstract

Abstract This report describes the synthesis of 6α, 17, 21-and 6β, 17, 21-trihydroxypregn-4- ene-3, 20-dione, 6α, 7, 21-and 6β, 11β, 21-trihydroxypregn-4-ene-3, 20-dione, and-for the first time-that of 6α, 21-and 6β, 21-dihydroxypregn-4-ene-3, 11, 20-trione. The former four compounds were prepared by 6-hydroxylation of 17, 21-trihydroxypregn-4-ene-3, 20-dione and 11β, 21-dihydroxypregn-4-ene-3, 20-dione, respectively. This was achieved by ...