Application of the McMurry coupling reaction in the synthesis of tri-and tetra-arylethylene analogues as potential cancer chemotherapeutic agents

…, TE Strecker, E Hamel, ML Trawick, KG Pinney

Index: Tanpure, Rajendra P.; Harkrider, Amanda R.; Strecker, Tracy E.; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 19 p. 6993 - 7001

Full Text: HTML

Citation Number: 12

Abstract

Structural redesign of selected non-steroidal estrogen receptor binding compounds has previously been successful in the discovery of new inhibitors of tubulin assembly. Accordingly, tetra-substituted alkene analogues (21–30) were designed based in part on combinations of the structural and electronic components of tamoxifen and combretastatin A- 4 (CA4). The McMurry coupling reaction was used as the key synthetic step in the ...