A Practical Oxidative Method for the Cleavage of Hydrazide N N Bonds

R Fernandez, A Ferrete, JM Llera…

Index: Fernandez, Rosario; Ferrete, Ana; Llera, Jose M.; Magriz, Antonio; Martin-Zamora, Eloisa; Diez, Elena; Lassaletta, Jose M. Chemistry - A European Journal, 2004 , vol. 10, # 3 p. 737 - 745

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Citation Number: 35

Abstract

Abstract The selective N-oxidation of the most nucleophilic amino nitrogen atom in hydrazides is central to the development of an unprecedented methodology for the cleavage of their N [BOND] N bonds under oxidative conditions. Treatment of a series of hydrazides 1– 9 with peracids such as magnesium monoperoxyphtalate hexahydrate (MMPP⋅ 6 H 2 O) or meta-chloroperbenzoic acid (m-CPBA) afforded the corresponding amides 10–16 in good ...