New metabolites from fungal biotransformation of an oral contraceptive agent: Methyloestrenolone
S Zafar, M Bibi, S Yousuf, MI Choudhary
Index: Zafar, Salman; Bibi, Marium; Yousuf, Sammer; Choudhary, M. Iqbal Steroids, 2013 , vol. 78, # 4 p. 418 - 425
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Citation Number: 11
Abstract
Fungal cell cultures were used for the first time for the biotransformation of methyloestrenolone (1), an oral contraceptive. Fermentation of 1 with Macrophomina phaseolina, Aspergillus niger, Gibberella fujikuroi, and Cunninghamella echinulata produced eleven metabolites 2–12, six of which 2–5, 11 and 12 were found to be new. These metabolites were resulted from the hydroxylation at C-1, C-2, C-6, C-10, C-11, and ...
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