Tetrahedron

Musk or violet? Design, synthesis and odor of seco-derivates of a musky carotol lead

P Kraft, K Popaj

Index: Kraft, Philip; Popaj, Kasim Tetrahedron, 2006 , vol. 62, # 52 p. 12211 - 12219

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Citation Number: 10

Abstract

By a six-step synthetic route consisting of a Li2MnCl4-catalyzed coupling of branched alkyl magnesium chlorides with isovaleryl and 3, 3-dimethylbutanoyl chloride, Grignard reaction of the product with ethynyl magnesium bromide, dehydration and transformation into a Grignard reagent, subsequent reaction with acetaldehyde,(E)-selective hydrogenation of the alkynol triple bond with lithium aluminum hydride, and finally pyridinium chlorochromate ...