Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1, 3-diols and 2-Aminoethanols 1, 2

…, K Teshima, K Chiba, S Sasaki, T Fujita

Index: Fujita, Tetsuro; Hirose, Ryoji; Yoneta, Masahiko; Sasaki, Shigeo; Inoue, Kenichiro; Kiuchi, Masatoshi; Hirase, Susumu; Chiba, Kenji; Sakamoto, Hiroshi; Arita, Masafumi Journal of Medicinal Chemistry, 1996 , vol. 39, # 22 p. 4451 - 4459

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Citation Number: 244

Abstract

A series of 2-substituted 2-aminopropane-1, 3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ...