Pyrrole chemistry XXV: A simplified synthesis of some 3-substituted pyrroles

…, HJ Anderson, NJ Gogan, CE Loader, R McDonald

Index: Xu, Ru Xun; Anderson, Hugh J.; Gogan, Niall J.; Loader, Charles E.; McDonald, Robert Tetrahedron Letters, 1981 , vol. 22, # 49 p. 4899 - 4900

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Citation Number: 62

Abstract

1-Benzenesulfonylpyrrole has been prepared by the reaction of pyrrolylpotassium and benzenesulfonyl chloride Tetrahedron Letters (1968), p. 1721 We have found that this compound can more conveniently be prepared by the phase-transfer reaction (V. 0. Illi, Synthesis, 136, (1979)) in which a solution of pyrrole in dichloromethane reacts with benzenesulfonyl chloride and sodium hydroxide in the presence of the phase-transfer catalyst tetrabutylammonium hydrogen sulfate to give ...