Tetrahedron Letters

High-yielding TfOH-catalyzed condensation of phenols with aromatic aldehydes at high pressure. A model synthesis of the benzylidene biphenol key skeleton of …

T Ohishi, T Kojima, T Matsuoka, M Shiro, H Kotsuki

Index: Ohishi, Takeshi; Kojima, Tomoyuki; Matsuoka, Tatsuomi; Shiro, Motoo; Kotsuki, Hiyoshizo Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2493 - 2496

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Citation Number: 37

Abstract

An approach to the benzylidene biphenol key component of blepharismins, photoreceptor pigments isolated from Blepharisma japonicum, is reported. This method relies on an efficient TfOH-catalyzed condensation of phenols with aromatic aldehydes in EtOH as a solvent at 3 kbar pressure.