Verbesserte Synthese von N1??Pyridylthiaminpyrophosphat, einem coenzymatisch aktiven Analogon des Thiaminpyrophosphates

…, B Fahlbusch, A Schellenberger

Index: Neef, Holger; Golbik, Ralph; Fahlbusch, Baerbel; Schellenberger, Alfred Liebigs Annalen der Chemie, 1990 , # 9 p. 913 - 916

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Abstract

Our previously published synthesis of the N'-pyridyl analog proved preparations of other intermediates are also described. 1 b of thiamine pyrophosphate6) is improved resulting in a re-The N'-pyridylthiamine pyrophosphate analog 1 b has been markably higher yield. Key reaction of this new synthetic separated and purified by ion exchange chromatography on pathway is the oxidative degradation of 5-acetylpyridine 8 to Sephadex A-25. the 5- ...