Development of a Regioselective N-Methylation of (Benz) imidazoles Providing the More Sterically Hindered Isomer
E Van Den Berge, R Robiette
Index: Van Den Berge, Emilie; Robiette, Raphael Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12220 - 12223
Full Text: HTML
Citation Number: 4
Abstract
An efficient and highly regioselective N-methylation of (NH)-(benz) imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.
Related Articles:
Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate
[Holden, Kenneth G; Mattson, Matthew N; Cha, Kyung Hoi; Rapoport, Henry The Journal of organic chemistry, 2002 , vol. 67, # 17 p. 5913 - 5918]
[Iddon, Brian; Lim, Bee Lan Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 4 p. 735 - 739]
A convenient synthesis of 1, 4-disubstituted imidazoles
[Tetrahedron Letters, , vol. 45, # 28 p. 5529 - 5532]
[Iddon, Brian; Lim, Bee Lan Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 4 p. 735 - 739]