Synthetic communications

Versatile Spirocyclic Glycine??Based Nitrones and Their Highly Stereoselective 1, 3??Dipolar Cycloaddition

S Cheng, H Wu, X Hu

Index: Cheng, Shangli; Wu, Huimin; Hu, Xianmin Synthetic Communications, 2007 , vol. 37, # 2 p. 297 - 308

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Citation Number: 7

Abstract

Abstract A convenient and efficient method for the synthesis of novel spirocyclic nitrones prepared from glycine derivatives is reported. The 1, 3??cycloaddition reactions of the nitrones with alkenes lead to novel isoxazolidines in high yields and with excellent regio?? and stereoselectivity.