Synthesis and structural studies of 5, 12-dioxocyclams capped by 4-substituted pyridines across the amine nitrogens

M Achmatowicz, LS Hegedus…

Index: Achmatowicz, Michal; Hegedus, Louis S.; David, Scott Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7661 - 7666

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Citation Number: 22

Abstract

A series of 4-substituted pyridine-capped 5, 12-dioxocyclams was synthesized and fully characterized. The 4-substituent varied from electron-withdrawing groups (NO2, NO, CN) to electron-donating groups (NHCbz, NH2). The most versatile substituent was the 4-bromo group, which could be replaced by a variety of groups using Stille, Sonogashira, or Buchwald-Hartig palladium-catalyzed chemistry. Copper complexes of a majority of these ...