Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands

…, E Hernández, R Pérez, R Cubí…

Index: Boes, Michael; Sleight, Andrew J.; Godel, Thierry; Martin, James R.; Riemer, Claus; Stadler, Heinz European Journal of Medicinal Chemistry, 2001 , vol. 36, # 2 p. 165 - 178

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Citation Number: 100

Abstract

... Journal of Medicinal ... figure Scheme 3 a. a (i) N-Methyl-4-piperidone, NaOMe, MeOH, 48 h, reflux; (ii) H 2 , Pd/C, EtOH; (iii) R 1 SO 2 Cl, pyridine. ... The piperidine derivatives were treated with the appropriate sulfonyl chlorides to afford the final compounds 23a−j. figure Scheme 4 a. ...