Chemical and pharmaceutical bulletin

Synthesis of 2-(pyrimidin-4-yl) indoles

LH Franco, JA Palermo

Index: Franco, Laura Hernandez; Palermo, Jorge Alejandro Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 975 - 977

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Citation Number: 30

Abstract

The synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as the key reaction.