exo-N-[2-(4-Azido-2, 3, 5, 6-tetrafluorobenzamido) ethyl]-dC: a novel intermediate in the synthesis of dCTP derivatives for photoaffinity labelling

C Cismaş, T Gimisis

Index: Cismas, Crina; Gimisis, Thanasis Tetrahedron Letters, 2008 , vol. 49, # 8 p. 1336 - 1339

Full Text: HTML

Citation Number: 3

Abstract

An alternative route for the synthesis of a photoaffinity labelling (PAL) dCTP derivative is reported. This method involves the intermediacy of exo-N-[2-(4-azido-2, 3, 5, 6- tetrafluorobenzamido) ethyl]-dC. The latter is prepared from the coupling of known N-(2- aminoethyl)-4-azido-2, 3, 5, 6-tetrafluorobenzamide, prepared in an improved three-step sequence, with an activated 4-triazolyl derivative of dU, followed by deprotection. 19F ...