Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury

…, M Zhang, N Blakeman, P Datta, H Pham…

Index: Prior, Allan M.; Zhang, Man; Blakeman, Nina; Datta, Palika; Pham, Hung; Chen, Qian; Young, Lindon H.; Weis, Margaret T.; Hua, Duy H. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1057 - 1061

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Citation Number: 2

Abstract

Abstract Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized and their inhibitions of long chain fatty acyl-CoA synthetase (ACSL) were examined. Two methods, a cell-based assay of ACSL activity and an in situ [14 C]-palmitate incorporation into extractable lipids were ...