Novel quinoline and naphthalene derivatives as potent antimycobacterial agents

…, PD Shinde, MP Sarmah, J Chattopadhyaya

Index: Upadhayaya, Ram Shankar; Vandavasi, Jaya Kishore; Kardile, Ramakant A.; Lahore, Santosh V.; Dixit, Shailesh S.; Deokar, Hemantkumar S.; Shinde, Popat D.; Sarmah, Manash P.; Chattopadhyaya, Jyoti European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1854 - 1867

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Citation Number: 78

Abstract

We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at single-dose concentration (6.25 μg/mL). The compounds 22, 23, 26 and 27 inhibited the growth of M. tuberculosis H37Rv 99%, 90%, ...