Synthesis and biological evaluation of imidazo [1, 2-a] pyrimidines and imidazo [1, 2-a] pyridines as new inhibitors of the Wnt/β-catenin signaling

B Cosimelli, S Laneri, C Ostacolo, A Sacchi…

Index: Laneri; Sacchi; Abignente Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1265 - 1267

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Citation Number: 7

Abstract

Abstract Wnt/β-catenin signaling plays an important role in the regulation of embryonic development and tumorigenesis. Since its deregulation results in severe human diseases, especially cancer, the Wnt signaling pathway constitutes a promising platform for