Enantioselective Total Syntheses of Plectosphaeroic Acids B and C

SY Jabri, LE Overman

Index: Jabri, Salman Y.; Overman, Larry E. Journal of the American Chemical Society, 2013 , vol. 135, # 11 p. 4231 - 4234

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Citation Number: 7

Abstract

Evolution of the synthetic strategy that culminated in the first total syntheses of the structurally unique plectosphaeroic acids B (2) and C (3) is described. The successful enantioselective route to (+)-2 and (+)-3 proceeds in 6 and 11 steps from the known hexahydro-2 H-pyrazinopyrrolo [2, 3-b] indole-1, 4-dione 39, which in turn is available in enantiomerically pure form by chemical synthesis. The central challenge in this synthesis ...