Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

…, YN Liu, RYH Chen, KF Bastow, KH Lee, TS Wu

Index: Reddy, M. Vijaya Bhaskar; Su, Chung-Ren; Chiou, Wen-Fei; Liu, Yi-Nan; Chen, Rosemary Yin-Hwa; Bastow, Kenneth F.; Lee, Kuo-Hsiung; Wu, Tian-Shung Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7358 - 7370

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Citation Number: 71

Abstract

The chalcone skeleton (1, 3-diphenyl-2-propen-1-one) is a unique template that is associated with various biological activities. We synthesized Mannich bases of heterocyclic chalcones (9–47) using a one-step Claisen–Schmidt condensation of heterocyclic aldehydes with Mannich bases of acetophenones, and tested the target compounds for cytotoxicity against three human cancer cell lines (prostate, PC-3; breast, MCF-7; ...