Synthetic communications

Synthesis of Atamestane (SH 489): An Aromatase Inhibitor

M Lourdusamy, F Labrie, SM Singh

Index: Lourdusamy; Labrie; Singh Synthetic Communications, 1995 , vol. 25, # 22 p. 3655 - 3662

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Citation Number: 4

Abstract

Abstract Atamestane (SH 489) was synthesized from 17β-Acetoxy-1α-methyl-5α-androstan- 3-one. Thus dibromination followed by dehydrobromination of the A-ring gave dienone (5) in good yield, which was hydrolyzed and oxidized to give the title compound in 60% overall