Synthesis and fluorescent characteristics of imidazole–indocyanine green conjugates

C Pavlik, NC Biswal, FC Gaenzler, MD Morton…

Index: Pavlik, Christopher; Biswal, Nrusingh C.; Gaenzler, Faith Corbo; Morton, Martha D.; Kuhn, Liisa T.; Claffey, Kevin P.; Zhu, Quing; Smith, Michael B. Dyes and Pigments, 2011 , vol. 89, # 1 p. 9 - 15

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Citation Number: 28

Abstract

We have successfully synthesized imidazole-dye conjugates by linking imidazole and nitroimidazoleacetic acids to an indocyanine green (ICG) carboxylic acid derivative, using an ethanolamine linker. These dye-conjugates show absorbance peaks at 754–756 nm and fluorescence peaks at 780 nm. The dye-conjugates show a blue shift of 25 nm and 30 nm in the absorption and fluorescence spectra respectively when compared to that of standard ...