Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4

YY Cheung, R Zamorano, AL Blobaum…

Index: Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R. ACS Combinatorial Science, 2011 , vol. 13, # 2 p. 159 - 165

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Citation Number: 5

Abstract

Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu4, a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu4 provide critical ...