Hydrolysis of 5, 5-Disubstituted Barbituric Acids

M Freifelder, AO GEISZLER…

Index: Freifelder,M. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 203 - 206

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Citation Number: 12

Abstract

A rapid and simple method of hydrolysis of 5, 5disubstituted barbituric acids to the corresponding amides is reported. High yields are obtained when the reactions are carried out in dilute aqueous ammonia at 200" for five to ten minutes. In only one case was acylated urea obtained. Twenty-three of the compounds reported are new.