Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes

…, MG Madej, R Panisch, M Lafontaine…

Index: Nasiri, Hamid Reza; Madej, M. Gregor; Panisch, Robin; Lafontaine, Michael; Bats, Jan W.; Lancaster, C. Roy D.; Schwalbe, Harald Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9530 - 9541

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Citation Number: 13

Abstract

Novel naphthoquinones were designed, synthesized, and tested as substrate-based inhibitors against the membrane-embedded protein quinol/fumarate reductase (QFR) from Wolinella succinogenes, a target closely related to QFRs from the human pathogens Helicobacter pylori and Campylobacter jejuni. For a better understanding of the hitherto structurally unexplored substrate binding pocket, a structure–activity relationship (SAR) ...