Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography

T Sargent III, AT Shulgin, CA Mathis

Index: Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077

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Citation Number: 20

Abstract

Note Added in Proof: A brief examination of uptake inhibition of NE, DA, and 5HT for 4, 19, and 37 (according to Horn, AS; Snyder, SHJ Pharmacol. Exp. Ther. 1972, 180, 523) showed rather weak activity. For 4 (100 nM), 19 (1000 nM), and 37 (1000 nM), percent inhibition values were 24, 37, and 26 for DA; 2, 85, and 40 for NE; and 5, 56, and 7 for 5HT, respectively. Ki values for imipramine were> 10000 nM for DA, 12 nM for NE, and 42 nM ...