A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
Z Cui, L Sun, B Zhang
Index: Cui, Zhiyong; Sun, Lele; Zhang, Biliang Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 927 - 933
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Citation Number: 8
Abstract
The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.
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