Tetrahedron

Total synthesis of lamellarins D, L, and N

…, T Ohta, T Yamaguchi, T Fukuda, F Ishibashi, M Iwao

Index: Fujikawa, Naotaka; Ohta, Takeshi; Yamaguchi, Tomohiro; Fukuda, Tsutomu; Ishibashi, Fumito; Iwao, Masatomo Tetrahedron, 2006 , vol. 62, # 4 p. 594 - 604

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Citation Number: 93

Abstract

Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki–Miyaura coupling of the 3, 4-dihydroxypyrrole bistriflate as the key reactions. The total yields of lamellarins D, L, and N from the common intermediate are 54, 58, and 50%, respectively.