Journal of heterocyclic chemistry

Synthesis of substituted 1, 2, 4??oxadiazoles from substituted acid chlorides and amidoximes under mild conditions

RO Bora, M Farooqui

Index: Bora, Rajesh O.; Farooqui, Mazahar Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 3 p. 645 - 649

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Citation Number: 11

Abstract

Oxadiazoles have often been described as bio-isosteres for amides and esters [1, 2, 3]. Due to increased hydrolytic [4] and metabolic stability of the oxadiazole ring, improved pharmacoknetic and in-vivo performance is often observed, which make these heterocycles an important structural motif for the pharmaceutical industry. As a consequence of these characteristics, oxadiazoles have impacted numerous drug discovery programs including ...