Selective Mono-Alkylation and Arylation of Dichlorobenzenes by Palladium-Catalyzed Grignard Cross-Coupling.

T Katayama, M Umeno

Index: Katayama, Tatsuo; Umeno, Masayuki Chemistry Letters, 1991 , p. 2073 - 2076

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Citation Number: 21

Abstract

Palladium (II)–phosphine complexes, especially PdCl 2 (dppf) where dppf stands for 1, 1′- bis (diphenylphosphino) ferrocene, are effective catalysts for the cross-coupling of Grignard reagents with dichlorobenzenes to produce selectively mono-alkylated and arylated benzenes. The addition of ligands is also effective for the cross-coupling of Grignard reagents containing a β-hydrogen (s).