Identification of type II and III DDR2 inhibitors

…, JR Simard, C Grütter, J Engel, D Rauh

Index: Getlik, Matthaeus; Gruetter, Christian; Simard, Jeffrey R.; Nguyen, Hoang D.; Robubi, Armin; Aust, Beate; Van Otterlo, Willem A.L.; Rauh, Daniel European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 1 - 15

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Citation Number: 10

Abstract

Discoidin domain-containing receptors (DDRs) exhibit a unique mechanism of action among the receptor tyrosine kinases (RTKs) because their catalytic activity is induced by extracellular collagen binding. Moreover, they are essential components in the assimilation of extracellular signals. Recently, DDRs were reported to be significantly linked to tumor progression in breast cancer by facilitating the processes of invasion, migration, and ...