Some nucleophilic substitutions in 2??cyano??3??nitroimidazo [1, 2??a] pyridine

L Arias, H Salgado??Zamora, E Campos…

Index: Arias, Lucina; Salgado-Zamora, Hector; Cervantes, Humberto; Campos, Elena; Reyes, Alicia; Taylor, Edward C. Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 565 - 569

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Citation Number: 7

Abstract

The imidazo [1, 2-a] pyridine ring is a versatile system which has shown an outstanding array of biological activities [1]. The incorporation of the imidazo [1, 2-a] pyridine moiety in structures investigated in relation to potential pharmacological activities has continued [2]. Electrophiles predominantly attack on the position 3 of the heterocycle [3]. Furthermore ipso electrophilic attack on 3-substituted (Br, NO2, CHO)-5-methylimidazo [1, 2-a] pyridines by ...