Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position

W Qian, JE Park, F Liu, KS Lee, TR Burke

Index: Qian, Wenjian; Park, Jung-Eun; Liu, Fa; Lee, Kyung S.; Burke Jr., Terrence R. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 3996 - 4003

Full Text: HTML

Citation Number: 7

Abstract

Protein–protein interactions (PPIs) mediated by the polo-box domain (PBD) of polo-like kinase 1 (Plk1) serve important roles in cell proliferation. Critical elements in the high affinity recognition of peptides and proteins by PBD are derived from pThr/pSer-residues in the binding ligands. However, there has been little examination of pThr/pSer mimetics within a PBD context. Our current paper compares the abilities of a variety of amino acid residues ...