Chemical research in toxicology

Nitroreduction of nitrated and C-9 oxidized fluorenes in vitro

CL Ritter, D Malejka-Giganti

Index: Ritter, Clare L.; Malejka-Giganti, Danuta Chemical Research in Toxicology, 1998 , vol. 11, # 11 p. 1361 - 1367

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Citation Number: 24

Abstract

Widespread environmental pollution with mutagenic and carcinogenic nitrofluorenes contributes to human health risks. Since nitroreduction leads to activation of many nitro compounds, nitroreduction of the nitrofluorene (NF) derivatives by one-and two-electron reductants was examined. Rates of nitroreduction catalyzed by xanthine oxidase (XO)/hypoxanthine and measured via stimulation of acetylated cytochrome c reduction ...