Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives

…, P Bansal, SG Vasanthraju, KK Srinivasan…

Index: Manohara Reddy; Mudgal, Jayesh; Bansal, Punit; Vasanthraju; Srinivasan; Rao, C. Mallikarjuna; Gopalan Kutty Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 384 - 392

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Citation Number: 15

Abstract

A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti- hyperlipidaemic activities. Compounds with thioxo-and oxoimidazole ring (1) and (2) have shown potent antioxidant activity with IC50 values 0.23±0.09 and 0.41±0.01 mM comparable with standard ascorbic acid. Compound (3) with a quinoxaline ring showed maximum ...