Development of a second generation coenzyme A analogue synthon

…, KW Vogel, DG Drueckhammer

Index: Bibart, Richard T.; Vogel, Kurt W.; Drueckhammer, Dale G. Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2903 - 2909

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Citation Number: 23

Abstract

We have previously reported a general synthetic approach to analogues of coenzyme A (CoA) which involves enzymatic synthesis of a general CoA analogue synthon having a thioester linkage in place of the amide bond nearest the thiol group (Martin et al. J. Am. Chem. Soc. 1994, 116, 4660). We report here the synthesis of a second CoA analogue synthon 1c which has the amide bond more distant from the thiol group replaced with a ...