Organic letters

Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction

K Asano, S Matsubara

Index: Asano, Keisuke; Matsubara, Seijiro Organic Letters, 2009 , vol. 11, # 8 p. 1757 - 1759

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Citation Number: 33

Abstract

Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper (Ι)-catalyzed azide− alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits the reaction.