Aminomethylation of lithiated nicotinamide: access to new pyridolactams

…, R Azzouz, G Deguest, C Fruit, L Bischoff, F Marsais

Index: Prieur, Emilie; Azzouz, Rabah; Deguest, Geoffrey; Fruit, Corinne; Bischoff, Laurent; Marsais, Francis Tetrahedron Letters, 2008 , vol. 49, # 3 p. 437 - 440

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Citation Number: 3

Abstract

New 2, 3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties.